We also discovered that ebselen, an organoselenium drug, was an inhibitor of CpGPI by high-throughput screening of 1,200 known drugs. An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Here, we report the first comprehensive high-resolution crystal structure analyses of the inhibitor-free form and the eight types of inhibitor (phosphate, erythrose 4-phosphate (E4P), arabinose 5-phosphate (A5P), sorbitol 6-phosphate (S6P), 6-phosphogluconic acid (6PGA), fructose 6-phosphate (F6P), glucose 6-phosphate (G6P), or mannose 6-phosphate (M6P)) complexes of mouse AMF (mAMF). FAQ. Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle. Glucose 6-phosphate (G6P, sometimes called the Robison ester) is a glucose sugar phosphorylated at the hydroxy group on carbon 6. Glucose-6-phosphate isomerase (GPI), alternatively known as phosphoglucose isomerase (PGI) or phosphohexose isomerase (PHI), is an enzyme that in humans is encoded by the GPI gene on chromosome 19. Glucose-6-phosphate isomérase – EC 5.3.1.9 L'α- D -glucose-6-phosphate est isomérisé en β- D -fructose-6-phosphate par la glucose-6-phosphate isomérase . In this study, we characterized the primary biochemical features of the C. parvum glucose-6-phosphate isomerase (CpGPI) and determined its Michaelis constant towards fructose-6-phosphate (Kvm = 0.309 mM, Vvmax = 31.72 nmol/μg/min). Isolated adult mouse ventricular cardiomyocytes (AMVMs) were treated for 24 h with or without the PGI inhibitor erythrose-4-phosphate (E4P, 3 µmol/L). However, no uncompetitive inhibitors were reported from those experiments. Dans le foie, la glucokinase, variante de l'hexokinase qui intervient dans le contrôle de la glycémie, ne sera pas régulée par le glucose-6-phosphate. This gene encodes a member of the glucose phosphate isomerase protein family. Glucose-6-Phosphate Isomerase ELISA Kits ... TIMP Metallopeptidase Inhibitor 3 (TIMP3) Triiodothyronine T3 (T3) Chemokine (C-C Motif) Ligand 2 (CCL2) Insulin (INS) Interleukin 12 (IL12) Apolipoprotein B (APOB) Interleukin 18 (IL18) Thyroxine T4 (T4) Apolipoprotein E (APOE) Haptoglobin (HP) Interleukin 12 beta (IL12B) Erythropoietin (EPO) Follicle-Stimulating Hormone (FSH) Interferon, … By using our services, you agree to our use of cookies. The encoded protein has been identified as a moonlighting protein based on its ability to perform … Correspondence to: Anja Karlstaedt, McGovern Medical School at The University of Texas Health Science Center at Houston, 6431 Fannin St, MSB 1.404, Houston, TX 77030. Glucose-6-phosphate isomerase is associated with disease activity and declines in response to infliximab treatment in rheumatoid arthritis. This dianion is very common in cells as the majority of glucose entering a cell will become phosphorylated in this way.. Because of its prominent position in cellular chemistry, glucose 6-phosphate has many possible fates within the cell. Recherche d'information médicale. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. [5] This gene encodes a member of the glucose phosphate isomerase protein family. Cette réaction est réversible, et demeure orientée vers la droite en raison de la concentration en β- D -fructose-6-phosphate, maintenue assez faible du fait de sa consommation immédiate par l'étape suivante de la glycolyse. This gene encodes a member of the glucose phosphate isomerase protein family. In addition, phosphoglucose isomerase has been shown to have functions equivalent to neuroleukin, autocrine motility factor, and maturation factor. There are no reviews for Glucose 6 phosphate isomerase Antibody (NBP1-90177). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount. Tested Reactivity: Hu. To prioritize the discovery of hits that bind to the same site occupied by steroids, we set up the primary … Glucose-6-phosphate isomerase (GPI) was purified to homogeneity from the skeletal muscle of crucian carp (Carassius auratus) by ammonium sulfate fractionation, column chromatographies of Q-Sepharose, SP-Sepharose, and Superdex 200 with a yield of 8.0%, and purification folds of 468. Phosphoglucose isomerase catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. 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